Analysis, opinion, and practical guidance on the topics that matter to STEM founders.
A practical guide covering typical round sizes, investor types, timelines, and the most common mistakes we see founders make.
A practical walkthrough of MDR, IVDR, FDA 510(k), and the EU AI Act for founders building AI-driven medical devices. What regulators need to see, and how to prepare before formal engagement begins.
Biomarker strategy is one of the most consequential decisions in early-stage drug development and one of the most commonly deferred. A practical guide to what to validate, how to sequence the work, and how to build a biomarker narrative that holds up under investor and regulatory scrutiny.
Architecture is a discipline about systems, not buildings. The structural principles that determine whether a building performs under load apply directly to how organisations are designed, scaled, and stress-tested. A technically grounded guide for founders building businesses that function under pressure.
Technical founders approach investor meetings with a consistent and preventable disadvantage. A practical guide to the five questions every investor is trying to answer, and how to structure a pitch that addresses them without sacrificing scientific credibility.
Most early-stage founders hire full-time senior leaders too late or too early. A practical guide to what a fractional executive actually is, when the model makes sense, and how to avoid the mistakes that make it fail.
Operational scale is not about adding headcount or process. It is about understanding which parts of your business are load-bearing and which are not. Most founder-led businesses get this wrong in predictable ways.
Most medtech founders treat UX as a design problem to be solved after the regulatory pathway is defined. It is not. Usability engineering is a mandatory regulatory requirement, and the UX decisions you make early will shape your submission, your timeline, and your clinical evidence requirements.
Practical articles on fundraising, product strategy, regulatory pathways, and go-to-market planning, delivered to your inbox.
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